Remaining Time

Müşerref Asuman Akgün

Dr. Müşerref  Asuman AKGÜN graduated from Hacettepe University Faculty of Pharmacy and Postgraduate Education Faculties, she worked as a Research Assistant at the Faculty of Medicine Akdeniz University Department of Pharmacology. One year after she received her Pharmacology Specialist Degree, she started to work in a pharmaceutical company as a Product Manager (PM).While working as PM, she achieved the dentists to be included in the active promotion plan for the first time in Turkey. She completed Master of Business Administration (MBA) program in English,”Graduate Program in International Management”at Istanbul University. While working as a Marketing Manager, she completed the "Executive Strategic Program in Management",which is specially designed for Administrators at Boğaziçi University. She continued her career as a Business Unit Manager (BUM) and also completed Ph.D. of Pharmacology Program by studying "Learned Helplessness and Learning" in Kocaeli University Medical Faculty. After the Ph.D.program, she started working as Assist. Prof. in Marmara University Faculty of Dentistry, Department of Pharmacology. At the same time, she also taught Master's lessons as a part-time faculty member in the Clinical Pharmacy Department of the Faculty of Pharmacy of Yeditepe University. She completed her Master’s degree in Phytotherapy at Yeditepe University. She also completed the Brand Communication and International Relations in Faculty of Economics at Anadolu University in order to carry out more integrated studies in the globalizing world. She is still working as a faculty member in Marmara University, Faculty of Dentistry,Department of Pharmacology.

Aging as a Risk Factor for Medication
The ageing process is of course a biological reality which has its own dynamic, largely beyond human control. The age of 65, roughly equivalent to retirement ages. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half-life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. Reduction in renal function in elderly subjects, particularly glomerular filtration rate, affects the clearance of many drugs such as water-soluble antibiotics  and nonsteroidal anti-inflammatory drugs.The clinical importance of such reductions of renal excretion is dependent on the likely toxicity of the drug. Drugs with a narrow therapeutic index like theophylline, digoxin, and lithium are likely to have serious adverse effects if they accumulate only marginally more than intended. Digoxin, and also lithium may cause some risk when taken together with non-steroidal anti-inflammatory drugs(NSAID s). Theophylline is strongly associated with erythromycin interaction; clarithromycin may also interact with this drug. Macrolides are also known to cause torsade des pointes and other ventricular arrhythmias, and a recent observational study prompted the FDA to strengthen the Warnings and Precautions section of azithromycin drug labels. Some medicines can trigger asthma symptoms, including the type of painkillers called NSAIDs. As the dentist we should prescribe right medications and increase life quality of elderly, both in terms of health and well-being of older people. WHO: Number of people over 60 years set to double by 2050; major societal changes required.Realigning health systems to the needs of older people will also be crucial. Establishing a health system in which the pharmacological dimension of dental treatments is involved, and in particular a health system in which systemic diseases and polypharmacy, drug-drug and drug-systemic disease interactions are taken into account, will benefit elderly patients and populations.